NRFTD Research

The following is a partial list of peer-reviewed publications based on work funded by the National Research Fund for Tick-Borne Diseases. Each of the publications in this list explicitly acknowledges NRFTD support.

2012

Hawley KL, Olson CM, Iglesias-Pedraz JM, et al. CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi. Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1228-32 http://www.ncbi.nlm.nih.gov/pubmed/22232682

Dunham-Ems SM, Caimano MJ, Eggers CH and Radolf JD. Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmission. PLoS Pathog. 2012 February; 8(2): e1002532 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280991

2011

Eggers CH, Caimano MJ, Malizia RA, et al. The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host. Mol Microbiol. 2011 Nov;82(3):679-97. http://www.ncbi.nlm.nih.gov/pubmed/21923763

Pappas CJ, Iyer R, Petzke MM, et al. Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycle. PLoS Pathog. 2011 July; 7(7): e1002102. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131272

Caimano MJ, Kenedy MR, Kairu T, et al. The hybrid histidine kinase Hk1 Is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticks. Infect Immun. 2011 August; 79(8): 3117–3130. http://www.ncbi.nlm.nih.gov/pubmed/21606185

2010

Banik S, Terekhova D, Iyer R, et al. BB0844, an RpoS-regulated protein, is dispensable for Borrelia burgdorferi infectivity and maintenance in the mouse-tick infectious cycle. Infect Immun. 2010 Dec 20 [Epub ahead of print]

Barthold SA, Hodzic, Imai DM, et al. Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. Antimicrob Agents Chemother. 2010;54(2): 643-51.

Huang B, Troese MJ, Howe D, et al. Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane. Microb Pathog. 2010; 49(5): 273-84.

Huang B, Hubber A, McDonough JA, et al. The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes. Cell Microbiol. 2010; 12(9): 1292-307.

Huang B, Troese MY, Ye S, et al. Anaplasma phagocytophilum APH_1387 is expressed throughout bacterial intracellular development and localizes to the pathogen-occupied vacuolar membrane. Infect Immun. 2010; 78(5): 1864–73.

XU H, Caimano MJ, Lin T, et al. Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferi. PLoS Pathog. 2010; 6(9): e1001104.

2009

Dunham-Ems SM, Caimano MJ, Pal U, et al. Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks. J Clin Invest. 2009; 119(12): 3652-65.

Grab DJ, Nyarko E, Nikolskaia OV, et al. Human brain microvascular endothelial cell traversal by Borrelia burgdorferi requires calcium signaling. Clin Microbiol Infect. 2009; 15(5): 422-6.

Saidac DS, Marras SAE, Parveen N. Detection and quantification of Lyme spirochetes using sensitive and specific molecular beacon probes. BMC Microbiol. 2009; 9: 43.

Troese MJ, Sarkar M, Galloway NL, et al. Differential expression and glycosylation of Anaplasma phagocytophilum major surface protein 2 paralogs during cultivation in Sialyl Lewis x-deficient host cells. Infect Immun. 2009; 77(5): 1746–56.